How to make a living
Houston,
Your husband can most likely get a job anywhere. In the last year several large Lakes Region employers have hired senior level IT folks, and more mid-level people. My company has a division that specializes in placing IT people and they are doing fine...that may change, but by the time you are ready to actually commit to relocate, the economy could be on the upswing again. Timing is everything.
The IT job won't be the challenge -- pharma will be. Definitely check out what others herein recommend -- DME, medical facilities (healthcare will continue to grow in a down economy), medical device manufacturers, etc. A good friend is a clinical data manager and worked a 6-month gig with a firm in Cambridge...much pharma and contractors in that area. While Boston may be a tough commute from the Lakes Region for you, there is the option of relocating along the 93 corridor in Southern NH and getting that much closer to the lakes region. Manchester is an hour from Boston (without traffic -- commuter traffic may increase that by car by 30-45 minutes, the there are trains you can take from the northern burbs).
Good luck,
GB
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